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[DOI] [PMC free article] [PubMed] [Google Scholar] 482.Theoharides T.C

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In a peer-reviewed review published in Aesthetic Medicine , researchers noted that rapid weight reduction impairs the skin's ability to regenerate and maintain elasticity leading to sagging, volume loss, and structural changes in the dermis, particularly in patients who are already past the collagen-decline threshold of their mid-thirties

It's a catastrophic failure point

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